In Laska et al:
No increased analgesia with increased doses of ibuprofen²

• In a double-blind, single-dose study of post-op dental pain
  involving 195 patients:

"…the three ibuprofen doses [400 mg, 600 mg, and
800 mg] did not differ significantly from each other…" ²

References: 1. Seymour RA, Ward-Booth P, Kelly PJ. Evaluation of different doses of soluble ibuprofen and ibuprofen tablets in postoperative dental pain. Br J Oral Maxillofac Surg. 1996;34:110-114. 2. Laska EM, Sunshine A, Marrero I, et al. The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther. 1986;40:1-7. 3. Winter L Jr, Bass E, Recant B, Cahaly JF. Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain. Oral Surg. 1978;45:159-166. 4. Kellstein DE, Lipton RB, Geetha R, et al. Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study. Cephalalgia. 2000;20:233-243.