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About Opioids and Constipation

The usual schedule is one dose every other day, as needed, but no more frequently than one dose in a 24-hour period.1

RECOMMENDED DOSE1

Patients whose weight falls outside of these ranges should be dosed at 0.15 mg/kg. The injection volume for these patients should be calculated using one of the following:

  • Multiply the patient weight in pounds by 0.0034 and round up the volume to the nearest 0.1 mL
  • Multiply the patient weight in kilograms by 0.0075 and round up the volume to the nearest 0.1 mL
RELISTOR is available in single-use vials for subcutaneous injection1
No dose adjustment required in elderly patients1
No dose adjustment required in patients with mild or moderate renal or hepatic impairment1
Dose reduction by one half is recommended in patients with severe renal impairment (creatinine clearance less than 30 mL/min)1
The effect of severe hepatic impairment or end-stage renal impairment requiring dialysis on the pharmacokinetics of RELISTOR has not been studied1

Patient and caregiver injection guidance

 

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