Relative Dose Intensity

TORISEL patients on average received 92% of the planned weekly dose¹

• TORISEL mean weekly dose was 23 mg, and the max planned weekly dose was 25 mg¹
• IFN-α mean weekly dose was 30 MU, and the max planned weekly dose was 54 MU¹

Reasons For Discontinuation

Patient discontinuation due to adverse events was 7.2% with TORISEL²

* Subjects with a global deterioration of health status requiring discontinuation of treatment without objective evidence
   of disease progression at that time should be classified as having “symptomatic deterioration.”²
† Other reasons for discontinuation in the TORISEL arm were disease progression and investigator’s decision.²
‡ Other reasons for discontinuation in the IFN-α arm were lost to follow up, investigator’s discretion, patient underwent
   surgery, and patient’s request.²

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